Detalhe da pesquisa
1.
Rational design of a new antibiotic class for drug-resistant infections.
Nature
; 597(7878): 698-702, 2021 09.
Artigo
Inglês
| MEDLINE | ID: mdl-34526714
2.
Characterization of Acinetobacter baumannii-calcoaceticus complex isolates and microbiological outcome for patients treated with sulbactam-durlobactam in a phase 3 trial (ATTACK).
Antimicrob Agents Chemother
; 68(5): e0169823, 2024 May 02.
Artigo
Inglês
| MEDLINE | ID: mdl-38567976
3.
I n vitro pharmacokinetics/pharmacodynamics of the ß-lactamase inhibitor, durlobactam, in combination with sulbactam against Acinetobacter baumannii-calcoaceticus complex.
Antimicrob Agents Chemother
; 68(1): e0031223, 2024 Jan 10.
Artigo
Inglês
| MEDLINE | ID: mdl-38092676
4.
Sulbactam-durlobactam susceptibility test method development and quality control ranges for MIC and disk diffusion tests.
J Clin Microbiol
; 62(1): e0122823, 2024 01 17.
Artigo
Inglês
| MEDLINE | ID: mdl-38095417
5.
Durlobactam, a Broad-Spectrum Serine ß-lactamase Inhibitor, Restores Sulbactam Activity Against Acinetobacter Species.
Clin Infect Dis
; 76(Suppl 2): S194-S201, 2023 05 01.
Artigo
Inglês
| MEDLINE | ID: mdl-37125470
6.
Molecular drivers of resistance to sulbactam-durlobactam in contemporary clinical isolates of Acinetobacter baumannii.
Antimicrob Agents Chemother
; 67(11): e0066523, 2023 11 15.
Artigo
Inglês
| MEDLINE | ID: mdl-37843305
7.
In Vitro Activity of Sulbactam-Durlobactam against Global Isolates of Acinetobacter baumannii-calcoaceticus Complex Collected from 2016 to 2021.
Antimicrob Agents Chemother
; 66(9): e0078122, 2022 09 20.
Artigo
Inglês
| MEDLINE | ID: mdl-36005804
8.
In Vitro Antibacterial Activity and In Vivo Efficacy of Sulbactam-Durlobactam against Pathogenic Burkholderia Species.
Antimicrob Agents Chemother
; 65(3)2021 02 17.
Artigo
Inglês
| MEDLINE | ID: mdl-33318017
9.
In Vitro Activity of Sulbactam-Durlobactam against Acinetobacter baumannii-calcoaceticus Complex Isolates Collected Globally in 2016 and 2017.
Antimicrob Agents Chemother
; 64(4)2020 03 24.
Artigo
Inglês
| MEDLINE | ID: mdl-31988095
10.
N-Hydroxyformamide LpxC inhibitors, their in vivo efficacy in a mouse Escherichia coli infection model, and their safety in a rat hemodynamic assay.
Bioorg Med Chem
; 28(24): 115826, 2020 12 15.
Artigo
Inglês
| MEDLINE | ID: mdl-33160146
11.
Determination of MIC Quality Control Ranges for the Novel Gyrase Inhibitor Zoliflodacin.
J Clin Microbiol
; 57(9)2019 09.
Artigo
Inglês
| MEDLINE | ID: mdl-31315953
12.
Frequency and Mechanism of Spontaneous Resistance to Sulbactam Combined with the Novel ß-Lactamase Inhibitor ETX2514 in Clinical Isolates of Acinetobacter baumannii.
Antimicrob Agents Chemother
; 62(2)2018 02.
Artigo
Inglês
| MEDLINE | ID: mdl-29133555
13.
Small-molecule inhibitors of gram-negative lipoprotein trafficking discovered by phenotypic screening.
J Bacteriol
; 197(6): 1075-82, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25583975
14.
Novel antibacterial targets and compounds revealed by a high-throughput cell wall reporter assay.
J Bacteriol
; 197(10): 1726-34, 2015 May.
Artigo
Inglês
| MEDLINE | ID: mdl-25733621
15.
Molecular mechanisms of sulbactam antibacterial activity and resistance determinants in Acinetobacter baumannii.
Antimicrob Agents Chemother
; 59(3): 1680-9, 2015 Mar.
Artigo
Inglês
| MEDLINE | ID: mdl-25561334
16.
Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy.
Antimicrob Agents Chemother
; 59(12): 7743-52, 2015 Dec.
Artigo
Inglês
| MEDLINE | ID: mdl-26438502
17.
Discovery and Characterization of New Hydroxamate Siderophores, Baumannoferrin A and B, produced by Acinetobacter baumannii.
Chembiochem
; 16(13): 1896-1904, 2015 Sep 07.
Artigo
Inglês
| MEDLINE | ID: mdl-26235845
18.
Clinical Outcomes for Patients With Monomicrobial vs Polymicrobial Acinetobacter baumannii-calcoaceticus Complex Infections Treated With Sulbactam-Durlobactam or Colistin: A Subset Analysis From a Phase 3 Clinical Trial.
Open Forum Infect Dis
; 11(4): ofae140, 2024 Apr.
Artigo
Inglês
| MEDLINE | ID: mdl-38595956
19.
Inhibiting Mycobacterium abscessus Cell Wall Synthesis: Using a Novel Diazabicyclooctane ß-Lactamase Inhibitor To Augment ß-Lactam Action.
mBio
; 13(1): e0352921, 2022 02 22.
Artigo
Inglês
| MEDLINE | ID: mdl-35073757
20.
Durlobactam, a New Diazabicyclooctane ß-Lactamase Inhibitor for the Treatment of Acinetobacter Infections in Combination With Sulbactam.
Front Microbiol
; 12: 709974, 2021.
Artigo
Inglês
| MEDLINE | ID: mdl-34349751